TY - JOUR T1 - EFFECT OF SODIUM NITROPRUSSIDE ON FUNCTION IN THE ISOLATED AND INTACT DOG KIDNEY JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 244 LP - 249 VL - 181 IS - 2 AU - ROBERT D. BASTRON AU - GEORGE J. KALOYANIDES Y1 - 1972/05/01 UR - http://jpet.aspetjournals.org/content/181/2/244.abstract N2 - We examined that effect of sodium nitroprusside on function in the isolated and intact dog kidney to determine whether the vasodilating action of this agent might protect the kidney against the renal response to systemic hypotesion. Sodium nitroprusside was infused directly into the renal artery of an isolated kidney from which it gained access to the systemic circulation of the perfusion dog. The rate of infusion was adjusted to reduce systemic pressure in the dog to below 85 mm Hg. However, the perfusion system employed permitted us to maintain the perfusion pressure of the isolated kidney constant. Sodium nitroprusside caused a 10% increase in renal blood flow in the isolated kidney, which, in time face of a constant perfusion pressure, reflected a decrease in renal vascular resistance. Inulin clearance did not change but sodium excretion increased significantly. Systemic arterial pressure decreased from 134 ± 5 mm Hg to 69 ± 3 mm Hg and was due primarily to a decrease in peripheral vascular resistance. In contrast to the response seen in the isolated kidney, this degree of hypotension was associated with marked decreases in p-aminohipputrate clearance, inulin clearance and sodium excretion. These data indicate that sodium nitroprusside is a potent vasodepressor which causes systemic hypotension primarily through peripheral vasodilatation. However, this agent has only a weak vasodilating effect on the renal vascular bed and thus provides no protection against the renal ischemia associated with hypotension. © 1972 by The Williams & Wilkins Co. ER -