TY - JOUR T1 - RENAL EFFECTS OF URICOSURIC AGENTS IN THE CHIMPANZEE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 591 LP - 599 VL - 177 IS - 3 AU - G. M. FANELLI, JR. AU - D. L. BORN AU - S. S. REILLY Y1 - 1971/06/01 UR - http://jpet.aspetjournals.org/content/177/3/591.abstract N2 - The renal effects of known uricosuric agents have been studied by standard clearance techniques in male chimpanzees. Probenecid, sulfinpyrazone and zoxazolaznine were orally active. Low doses of probenecid elicited a modest uricosuric effect suggesting that the renal transport of urate in this species may be more sensitive than that which obtains in man. Salicylate and carinamide were uricosuric; iodopyracet at high loads was also strongly uricosuric. Chlorothiazide administered i.v. produced a very transient increase in uric acid excretion similar to that seen in man. © 1971 by The Williams & Wilkins Co. ER -