PT  - JOURNAL ARTICLE
AU  - NICHOLAS R. BACHUR
TI  - DAUNORUBICINOL, A MAJOR METABOLITE OF DAUNORTJBICIN: ISOLATION FROM HUMAN URINE AND ENZYMATIC REACTIONS
DP  - 1971 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 573--578
VI  - 177
IP  - 3
4099  - http://jpet.aspetjournals.org/content/177/3/573.short
4100  - http://jpet.aspetjournals.org/content/177/3/573.full
SO  - J Pharmacol Exp Ther1971 Jun 01; 177
AB  - A major metabolite of daunorubicin from human urine and enzymatic reactions was isolated and characterized. Comparative data from thin-layer chromatography, infrared spectroscopy, mass spectroscopy and chemical derivatization of daunorubicin, adriamycin and the metabolite indicated the metabolite to be the 13-hydroxydaunorubicin, daunorubicinol. The hydrolytic product of daunorubicinol, daunorubicinol aglycone, was a second metabolite. © 1971 by The Williams & Wilkins Co.