TY - JOUR T1 - GANGLIONIC STIMULATION: MECHANISM OF THE POSITIVE INOTROPIC AND CHRONOTROPIC EFFECTS OF ANGIOTENSIN JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 48 LP - 55 VL - 177 IS - 1 AU - WILLIAM C. FARR AU - GUNTER GRUPP Y1 - 1971/04/01 UR - http://jpet.aspetjournals.org/content/177/1/48.abstract N2 - Angiotensin II given i.v. increases the heart rate and the contractile force of the dog heart by a sympathetic mechanism. These effects are reduced by crushing the caudal cervical ganglia or cutting their postganglionic fibers but not by destroying the stellate ganglia. Cardiac effects similar to those caused by i.v. injections are produced by an action of angiotensin in the vascular distribution of the right subclavian artery, supplying the right caudal cervical ganglion, but not by an action in the coronary circulation. We conclude that the sympathetically induced increase of heart rate and contractile force can be explained by one dominant mechanism: ganglionic stimulation. © 1971, by The Williams & Wilkins Company ER -