PT  - JOURNAL ARTICLE
AU  - WILLIAM C. FARR
AU  - GUNTER GRUPP
TI  - GANGLIONIC STIMULATION: MECHANISM OF THE POSITIVE INOTROPIC AND CHRONOTROPIC EFFECTS OF ANGIOTENSIN
DP  - 1971 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 48--55
VI  - 177
IP  - 1
4099  - http://jpet.aspetjournals.org/content/177/1/48.short
4100  - http://jpet.aspetjournals.org/content/177/1/48.full
SO  - J Pharmacol Exp Ther1971 Apr 01; 177
AB  - Angiotensin II given i.v. increases the heart rate and the contractile force of the dog heart by a sympathetic mechanism. These effects are reduced by crushing the caudal cervical ganglia or cutting their postganglionic fibers but not by destroying the stellate ganglia. Cardiac effects similar to those caused by i.v. injections are produced by an action of angiotensin in the vascular distribution of the right subclavian artery, supplying the right caudal cervical ganglion, but not by an action in the coronary circulation. We conclude that the sympathetically induced increase of heart rate and contractile force can be explained by one dominant mechanism: ganglionic stimulation. © 1971, by The Williams & Wilkins Company