TY - JOUR T1 - STRESS-MEDIATED DECREASE IN LIVER HEXOBARBITAL METABOLISM: THE ROLE OF CORTICOSTERONE AND SOMATOTROPIN JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 227 LP - 233 VL - 177 IS - 1 AU - EDDIE WEI AU - JOHN T. WILSON Y1 - 1971/04/01 UR - http://jpet.aspetjournals.org/content/177/1/227.abstract N2 - The liver metabolism of hexobarbital was studied in male rats subjected to stress (restraint and thermal stimuli). Hexobarbital metabolism did not change two hours after stress but was decreased 48 hours after the onset of stress. This effect of stress was noted in adrenalectomized but not in hypophysectomized rats. Simulation of hormonal conditions in stress by corticosterone or somatotropin injections showed no depression of hexobarbital metabolism in rats with high corticosterone levels. However, the liver metabolism of hexobarbital decreased 48 hours after administration of somatotropin to intact, corticosteronetreated, adrenalectomized or hypophysectomized rats. We propose that somatotropin is a pituitary hormone involved in the stress-mediated depression of hexobarbital metabolism. © 1971, by The Williams & Wilkins Company ER -