TY - JOUR T1 - IMMUNOPHARMACOLOGIC EFFECTS OF CYCLOLEUCINE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 501 LP - 513 VL - 180 IS - 2 AU - Marvin E. Rosenthale AU - Louis J. Datko AU - Jacob Kassarich AU - Eugene I. Rosanoff Y1 - 1972/02/01 UR - http://jpet.aspetjournals.org/content/180/2/501.abstract N2 - Cycloleucine (1-aminocyclopentane carboxylic acid) was shown to be quite active in preventing the clinical and histologic signs of experimental allergic encephalomyelitis and adjuvant arthritis. In contrast, it was inactive in two in vitro models designed to detect various types of clinically effective anti-inflammatory, anti-immune agents: tissue culture growth and polymorphonuclear leukocyte migration. Its immunopharmacologic spectrum differs from that of other clinically active agents, suggesting that it may work via a different mechanism or at a different site. © 1972 by The Williams & Wilkins Co. ER -