PT  - JOURNAL ARTICLE
AU  - LORENZ M. HOFMANN
AU  - MICHAEL I. KRUPNICK
AU  - HIDANIA A. GARCIA
TI  - INTERACTIONS OF SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE WITH ASPIRIN IN THE RAT AND DOG
DP  - 1972 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 1--5
VI  - 180
IP  - 1
4099  - http://jpet.aspetjournals.org/content/180/1/1.short
4100  - http://jpet.aspetjournals.org/content/180/1/1.full
SO  - J Pharmacol Exp Ther1972 Jan 01; 180
AB  - The influence of orally administered aspirin on the five-hour diuretic responses of spironolactone (S) and hydrochlorothiazide (HC) was evaluated as follows: 25, 100 and 300 mg/kg of aspirin were given with 20 mg/kg of S and 5 mg/kg of HC in male Badger rats injected s.c. with 50 µg of deoxycorticosterone acetate. After i.m. injection of 10 µg d-aldosterone in female mongrel dogs, aspirin was given in a dosage of 8 mg/kg with S at 2 and 8 mg/kg. In the presence (rat) and absence (dog) of observed diuretic responses to aspirin per se, coadministration of S resulted in a significant reduction of its specific mineralocorticoid blocking properties. Aspirin/S dosage ratios of 4:1 (dog) and 5:1 (rat) induced a net potassium loss in the rat and decreased natriuresis in the dog and, as a consequence, reduced the index (urinary Na/K ratio) of spironolactone's pharmacological activity at the renal level. The interaction of HC and aspirin was of a relatively lower order of sensitivity (absent at a 5:1 dosage ratio) with additive effects initially upon K excretion and later upon urine and Na output. © 1972, by The Williams & Wilkins Company