TY - JOUR T1 - CENTRAL NERVOUS SYSTEM EFFECTS OF FENFLURAMINE HYDROCHLORIDE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 110 LP - 117 VL - 180 IS - 1 AU - RONALD J. ZIANCE AU - I. GLENN SIPES AU - WILLIAM J. KINNARD, JR. AU - JOSEPH P. BUCKLEY Y1 - 1972/01/01 UR - http://jpet.aspetjournals.org/content/180/1/110.abstract N2 - Fenfluramine is a phenethylamine compound with a structure similar to that of amphetamine. These two structurally similar compounds possess several major differences in pharmacologic properties, especially with regard to their effects on the central nervous system. d-Amphetamine produced a dose-related increase of spontaneous motor activity (SMA) in mice; however, dl-fenfluramine decreased the SMA in a dose-related manner. Biocimemical studies revealed that dl-fenfluramine decreased the content of norepinephrine and dopamine in mouse and rat brain. Pretreatment of mice with a monoamine oxidase inhibitor reversed the effect of dl-fenfluramine from one of significant decrease of SMA to one of a marked increase of SMA; however, the ability of d-amphetamine to increase SMA of mice was enhanced by prior monoamine oxidase inhibition. These data suggest that d-amphetamine and dl-fenfluramine differ in their interaction with central adrenergic neurons to produce their respective SMA effects in mice. © 1972, by The Williams & Wilkins Company ER -