PT  - JOURNAL ARTICLE
AU  - J. C. WINTER
TI  - TOLERANCE TO A BEHAVIORAL EFFECT OF LYSERGIC ACID DIETHYLAMIDE AND CROSS-TOLERANCE TO MESCALINE IN THE RAT: ABSENCE OF A METABOLIC COMPONENT
DP  - 1971 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 625--630
VI  - 178
IP  - 3
4099  - http://jpet.aspetjournals.org/content/178/3/625.short
4100  - http://jpet.aspetjournals.org/content/178/3/625.full
SO  - J Pharmacol Exp Ther1971 Sep 01; 178
AB  - This investigation examined tolerance to lysergic acid diethylamide (LSD) after the administration of LSD on mescaline in rats responding on a fixed ratio schedule of positive reinforcement. After the requisite conditions were established for the development of tolerance in the behavioral situation, the same schedule of drug administration was applied to untrained animals and the levels of LSD in brain and liver were determined. In this way the metabolic component of tolerance was assessed. pretreatment with either LSD or mescaline for two days preceding the administration of LSD caused a diminution of the rate-depressant effect of LSD. This demonstration of tolerance to LSD and cross-tolerance to mescaline was in agreement with the results of other workers. Determination of the total amount and concentration of LSD in brain and liver revealed no significant differences between rats which received LSD for the first time and those pretreated with LSD or mescaline. These results indicate that there is no gross alteration in brain and liver levels of LSD concomitant with the development of tolerance to LSD on cross-tolerance of LSD to mescaline in the particular behavioral task studied. © 1971 by The Williams & Wilkins Co.