PT - JOURNAL ARTICLE AU - LARRY WHEELER AU - ALLEN STROTHER TI - <em>IN VITRO</em> METABOLISM OF THE N-METHYLCARBAMATES, ZECTRAN AND MESUROL, BY LIVER, KIDNEY AND BLOOD OF DOGS AND RATS DP - 1971 Aug 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 371--382 VI - 178 IP - 2 4099 - http://jpet.aspetjournals.org/content/178/2/371.short 4100 - http://jpet.aspetjournals.org/content/178/2/371.full SO - J Pharmacol Exp Ther1971 Aug 01; 178 AB - A comparative in vitro study of the rat and dog utilizing 15,000 x g liver and kidney homogenates and various blood fractions was done to determine the hydrolytic and metabolic activity toward the pesticides 4-dimethylamino-3,5-xylyl methylcarbamate (Zectran) and 4-methylthio-3,5-xylyl methylcarbamate(Mesurol). Data obtained from the liver, kidney and blood indicate that the rat and dog utilize the same major pathways of metabolism for Zectran and Mesurol. In the liver, the major route of metabolism for Zectran is N-dealkylation of the para-N-methyl groups. Sulfoxidation of the para-S-methyl group is the main metabolic pathway with Mesurol. Other significant routes with both Zectran and Mesurol are hydroxylation of the N-methyl moiety of the carbamate. Whole blood from both species possesses N-dealkylating properties but not sulfoxidation properties. Little CO2 is given off in vitro by the blood or the kidney. The kidney homogenate possesses less metabolic activity towards Zectran and Mesurol than whole blood and liver homogenates. Under in vitro conditions, 91 to 98% of Zectran and Mesurol is metabolically altered demonstrating the more extensive biodegradability of Zectran and Mesurol as opposed to the chlorinated hydrocarbons. © 1971 by The Williams &amp; Wilkins Co.