RT Journal Article
SR Electronic
T1 SOME EFFECTS OF GERMINE-3-MONOACETATE (GMA) ON ISOLATED RAT AND GUINEA-PIG ILEUM
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 181
OP 187
VO 177
IS 1
A1 W. J. GOLDMAN
A1 A. SCRIABINE
YR 1971
UL http://jpet.aspetjournals.org/content/177/1/181.abstract
AB Germine-3-monoacetate (GMA), 25 and 50 µg/ml caused a weak contraction of rat and guinea-pig ileum. It. had no effect on isolated ileum of 11-day-old rats. At 6 to 50 µg/ml, GMA potentiated the contractile response of guinea-pig ilcum to coaxial electrical stimulation and antagonized tile depressant effect of morphine. hut not of tetrodotoxin. At 25 or 50 µg/ml, GMA increased the release of acetylcholine from isolated guine-pig ileum. The results suggest that some effects of GMA on the smooth muscle may be mediated by release of acetylcholine. © 1971, by The Williams & Wilkins Company