RT Journal Article
SR Electronic
T1 METHYLTRANSFERASE ENZYMES IN RED BLOOD CELLS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 650
OP 654
VO 176
IS 3
A1 AXELROD, JULIUS
A1 COHN, CAL K.
YR 1971
UL http://jpet.aspetjournals.org/content/176/3/650.abstract
AB Catechol-O-methyltransferase, histamine-N-methyltransferase and a methanol-forming enzyme were identified in the red blood cells of humans and a variety of mammalian species. The properties of the transferase enzymes are described with respect to distribution in blood, co-factor requirements, products formed, species distribution and substrate specificity. The presence of the transferase enzyme in an easily accessible tissue in man makes possible a study of changes in these enzymes in different physiologic states, drug treatments and diseases. © 1971 by The Williams & Wilkins Co.