@article {MARCHAND232, author = {CLAUDE MARCHAND and STUART McLEAN and GABRIEL L. PLAA}, title = {THE EFFECT OF SKF 525A ON THE DISTRIBUTION OF CARBON TETRACHLORIDE IN RATS}, volume = {174}, number = {2}, pages = {232--238}, year = {1970}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Rats were pretreated with SKF 525A, 40 mg/kg i. p., and gavaged 40 minutes later with C14Cl4, 2 nil/kg (0.1 mc/kg). In rats sacrificed {\textonehalf}, 1 and 2 hours after C14Cl4 administration, there was significantly less toluene-soluble C14 in the blood, liver, brain, muscle and fatty tissue of rats pretreated with SKF 525A. No significant difference was observed 5{\textonehalf} hours after gavage and an increase in tissue C14 was found 12 hours after gavage in rats pretreated with SKF 525A. During the first six hours that followed C14Cl4 gavage, rats pretreated with SKF 525A excreted less toluene-soluble C14 through the lungs. When the pretreatment was performed 66 hours before administration of C14Cl4, there was a significant increase in blood C14Cl4 of pretreated rats. When CCl4 was administered i.p. or s.c., SKF 525A had no apparent effect on CCl4 distribution in rats sacrificed one hour after C14Cl4 administration. These results suggest that SKF 525A has a diphasic effect on the concentration of CCl4 in tissues, which is probably due to an effect on the gastrointestinal absorption of CCl4. This effect of SKF 525A could be a partial explanation for its protective effect on CCl4 toxicity. {\textcopyright} 1970 by The Williams \& Wilkins Co.}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/174/2/232}, eprint = {https://jpet.aspetjournals.org/content/174/2/232.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }