PT  - JOURNAL ARTICLE
AU  - CARL VOEGTLIN
AU  - HOMER W. SMITH
TI  - QUANTITATIVE STUDIES IN CHEMOTHERAPY. V INTRAVENOUS VERSUS INTRAMUSCULAR ADMINISTRATION OF ARSPHENAMINE. CURATIVE POWER AND MINIMUM EFFECTIVE DOSE
DP  - 1921 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 357--375
VI  - 17
IP  - 5
4099  - http://jpet.aspetjournals.org/content/17/5/357.short
4100  - http://jpet.aspetjournals.org/content/17/5/357.full
SO  - J Pharmacol Exp Ther1921 Jun 01; 17
AB  - 1. The intramuscular administration of arsphenamine and neoarsphenamine is just as efficacious as the intravenous administration of these drugs in the treatment of experimental trypanosomiasis, as judged by both the minimum effective dose and the percentage of survivals of treated animals. The significance of this point in the treatment of human syphilis is discussed. 2. The ratio of the minimum lethal dose to the minimum effective dose M. L. D./M. E. D., is a substantial index to the curative power of a given drug under experimental conditions.