RT Journal Article
SR Electronic
T1 CESIUM EFFECTS ON MUSCLE MEMBRANE RESPONSES TO QUATERNARY AMMONEUM IONS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 483
OP 488
VO 175
IS 2
A1 A. PORTELA
A1 J. VACCARI
A1 P. A. STEWART
A1 R. J. PEREZ
A1 J. C. PEREZ
YR 1970
UL http://jpet.aspetjournals.org/content/175/2/483.abstract
AB The depolarizing effects of acetyicholine, choline and carbamyicholine at the motor end-plate and in end-plate-free regions of frog sartorius muscles have been Studied in cesium Ringer's solution, in extension of earlier work in potassium Ringer's solution. The conclusion from previous studies in potassium Ringer's that two different quaternary ammonium ion-sensitive systems are operating in the muscle membrane is supported by the membrane responses in cesium Ringer's. No significant difference was seen in the response of the motor end-plate receptor in the two Ringer's solutions, but the increased stability of the end-plate-free region depolarization in cesium Ringer's suggests a significant change in quaternary ammonium ion binding characteristics of the conductance control system in this region. The magnitude of depolarization was greater in cesium Ringer's than had been found in potassium Ringer's for all three drugs. © 1970 by The Williams & Wilkins Co.