RT Journal Article
SR Electronic
T1 DEPENDENCE OF TETRODOTOXIN BLOCKAGE OF NERVE MEMBRANE CONDUCTANCE ON EXTERNAL pH
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 224
OP 228
VO 169
IS 2
A1 TOSHIO NARAHASHI
A1 JOHN W. MOORE
A1 DONALD T. FRAZIER
YR 1969
UL http://jpet.aspetjournals.org/content/169/2/224.abstract
AB The effectiveness of tetrodotoxin in blocking the peak transient sodium conductance of squid giant axons has been compared at pH 7 and pH 9 under voltage clamp conditions. Tetrodotoxin was much more potent at pH 7 than at pH 9, and the result is compatible with the concept that the cation forms of tetrodotoxin are mainly responsible for the blocking action. © 1969, by The Williams & Wilkins Co.