RT Journal Article
SR Electronic
T1 TENSION-RESPONSE RELATIONSHIPS IN THE INTACT NICTITATING MEMBRANE OF THE PITHED CAT
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 196
OP 200
VO 169
IS 2
A1 DAVID P. WESTFALL
A1 PAUL E. GILBERT
A1 WILLIAM W. FLEMING
YR 1969
UL http://jpet.aspetjournals.org/content/169/2/196.abstract
AB Increases in the resting tension, within the range of 0 to 12 g applied to the nictitating membrane, result in increases in the response to a constant dose of norepinephrine. Further increases in tension, up to 19 g, do not cause any further consistent changes in response. Dose-response curves determined under 1 to 2 g of resting tension, result in an apparent sensitivity which is only 1/10 of that determined under 10 to 12 g of resting tension. Denervation and decentralization, procedures which produce changes in the sensitivity of the nictitating membrane, cause little, if any, change in the relationship of response to resting tension. © 1969, by The Williams & Wilkins Co.