PT  - JOURNAL ARTICLE
AU  - DAVID P. WESTFALL
AU  - PAUL E. GILBERT
AU  - WILLIAM W. FLEMING
TI  - TENSION-RESPONSE RELATIONSHIPS IN THE INTACT NICTITATING MEMBRANE OF THE PITHED CAT
DP  - 1969 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 196--200
VI  - 169
IP  - 2
4099  - http://jpet.aspetjournals.org/content/169/2/196.short
4100  - http://jpet.aspetjournals.org/content/169/2/196.full
SO  - J Pharmacol Exp Ther1969 Oct 01; 169
AB  - Increases in the resting tension, within the range of 0 to 12 g applied to the nictitating membrane, result in increases in the response to a constant dose of norepinephrine. Further increases in tension, up to 19 g, do not cause any further consistent changes in response. Dose-response curves determined under 1 to 2 g of resting tension, result in an apparent sensitivity which is only 1/10 of that determined under 10 to 12 g of resting tension. Denervation and decentralization, procedures which produce changes in the sensitivity of the nictitating membrane, cause little, if any, change in the relationship of response to resting tension. © 1969, by The Williams & Wilkins Co.