PT  - JOURNAL ARTICLE
AU  - L. E. MAGARGAL
AU  - H. MAGARGAL
AU  - M. M. REIDENBERG
TI  - EFFECT OF STEROID HORMONES ON THE PARATHYROID HORMONE DOSE-RESPONSE CIJRVE
DP  - 1969 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 138--141
VI  - 169
IP  - 1
4099  - http://jpet.aspetjournals.org/content/169/1/138.short
4100  - http://jpet.aspetjournals.org/content/169/1/138.full
SO  - J Pharmacol Exp Ther1969 Sep 01; 169
AB  - The interaction between various steroid hormones and parathyroid hormone was studied by observing the effect of each of these steroids on the parathyroid hormone dose-response curve in thyroparathyroidectomized rats. Methylprednisolone, estradiol or testosterone was given to rats for 48 hours prior to injection of parathyroid hormone. Increase in serum calcium six hours after parathyroid hormone was defined as the response. The steroids lowered the initial serum calcium taken prior to parathyroid hormone. Methylprednisolone inhibited the response at all dose levels of parathyroid hormone. Estradiol and testosterone enhanced the response to low doses of parathyroid hormone and inhibited the response to high doses. © 1969, by The Williams & Wilkins Company