RT Journal Article
SR Electronic
T1 EXCRETION OF SULFOBROMOPHTHALEIN BY PERFUSED RAT LIVER AS INFLUENCED BY STEROIDAL HORMONES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 37
OP 42
VO 173
IS 1
A1 DESPOPOULOS, AGAMEMNON
YR 1970
UL http://jpet.aspetjournals.org/content/173/1/37.abstract
AB Eight steroids and stilbestrol were examined for their influences on hepato-biiary excretion of sulfobromophthalein. Three patterns of response were observed. 1) Cortisone transiently increased bile flow and reduced concentration and rate of excretion of sulfobromophthalein in the bile. 2) Norethandrolone, norethynodrel and Norlutin reduced rates of bile formation and of sulfobromophthalein excretion without affecting the concentrating mechanism for sulfobromophthalein. 3) Testosterone and methyltestosterone, estradiol, progesterone and stilbestrol irreversibly reduced the rate of bile formation and transiently reduced excretion and concentration of sulfobromophthalein. © 1970, by The Williams & Wilkins Company