RT Journal Article
SR Electronic
T1 THE DIURETIC ACTIVITY OF ETHACRYNIC ACID IN RATS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 210
OP 215
VO 163
IS 1
A1 G. R. ZINS
A1 R. A. WALK
A1 R. Z. GUSSIN
A1 C. R. ROSS
YR 1968
UL http://jpet.aspetjournals.org/content/163/1/210.abstract
AB Intravenous administration of large doses of ethacrynic acid to rats enhanced the excretion of sodium, potassium and chloride in the urine. Single doses of 37.5 and 125 mg/kg increased water and potassium excretion 2-fold, sodium excretion 3-fold and chloride excretion 4-fold in relation to parallel control animals. Single dose activity was confined to the 1st hr after injection whereas effects persisted for the duration of observation when animals were primed with 25 mg/kg and sustained with 50 mg/kg/hr. In no instance was toxicity apparent inthese studies. Thus, ethacrynic acid shares with organomercurial diuretics and the cardiac glycosides the characteristic of being less efficient but certainly not incapable of exerting its pharmacologic actions in the rat. © 1968, by The Williams & Wilkins Company