RT Journal Article SR Electronic T1 EFFECT OF A CHOLINESTERASE INHIBITOR WHEN INJECTED INTO THE MEDULLA OF THE RABBIT JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 309 OP 318 VO 162 IS 2 A1 WILLIAM C. STEWART A1 ESSIE A. ANDERSON YR 1968 UL http://jpet.aspetjournals.org/content/162/2/309.abstract AB Microinjections of the cholinesterase inhibitor sarin were used to explore the pons and medulla of the rabbit. Bilateral injections into the lateral reticular nucleus of the medulla at the level of the inferior fovea caused respiratory arrest. Respiration was quickly restored after atropine was given i.v. Other effects observed, and reversed by i.v. atropine, included acceleration of respiratory rate, bradycardia and hypotension. The results are interpreted as indicating the location of a nervous center concerned with the control of the respiratory muscles, which is the site of the central respiratory paralysis in systemic sarin poisoning. © 1968 by The Williams & Wilkins Co.