TY - JOUR T1 - NONSPECIFIC SUPERSENSITIVITY OF THE GUINEA-PIG ILEUM PRODUCED BY CHRONIC GANGLION BLOCKADE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 277 LP - 285 VL - 162 IS - 2 AU - WILLIAM W. FLEMING Y1 - 1968/08/01 UR - http://jpet.aspetjournals.org/content/162/2/277.abstract N2 - Chronic treatment with chlorisondamine (1.0 mg/kg) three times per day for 5 to 7 days has been demonstrated to produce supersensitivity of the isolated ileum to acetylcholine, histamine, potassium and 5-UT. One day of treatment with chlorisondamine did not alter the sensitivity. Simultaneous pretreatment with carbachol inhibited the development of supersensitivity by chronic ganglion blockade. The supersensitivity could not be demonstrated if the control and pretreated preparations were both in depolarzing K2SO4-Ringer's solution. It is concluded that a nonspecific supersensitivity develops in the guinea-pig ileum as a result of chronically reduced activity in the smooth muscle. The results further strengthen the hypothesis that nonspecific supersensitivity is caused by a physiologic change in the smooth muscle beyond the receptors, perhaps in the cell membrane. © 1968 by The Williams & Wilkins Co. ER -