PT  - JOURNAL ARTICLE
AU  - LEMONT B. KIER
TI  - THE PREFERRED CONFORMATIONS OF EPHEDRINE ISOMERS AND THE NATURE OF THE <em>ALPHA</em> ADRENERGIC RECEPTOR
DP  - 1968 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 75--81
VI  - 164
IP  - 1
4099  - http://jpet.aspetjournals.org/content/164/1/75.short
4100  - http://jpet.aspetjournals.org/content/164/1/75.full
SO  - J Pharmacol Exp Ther1968 Nov 01; 164
AB  - The preferred conformations of ephedrine and Ψ-ephedrine isomers have been deduced from molecular orbital calculations of total energy as a function of molecular geometry. A pattern of complementary features has been proposed which represents the alpha adrenergic receptor. The declining order of alpha adrenergic activity of the four isomers of ephedrine is explained satisfactorily by this proposed receptor model. © 1968, by The Williams & Wilkins Company