RT Journal Article
SR Electronic
T1 INHIBITION OF THE METABOLISM OF H3-MELATONIN BY PHENOTHIAZINES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 367
OP 372
VO 161
IS 2
A1 Richard J. Wurtman
A1 Julius Axelrod
A1 Fernando Anton-Tay
YR 1968
UL http://jpet.aspetjournals.org/content/161/2/367.abstract
AB After rats are treated acutely with chlorpromazine, there is an elevation in the level of i.v. administered H3-melatonin in brain and blood. This effect is not the result of the hypothermia produced by chlorpromazine. Other phenothiazines, such as promazine and promethazine, also elevate tissue H3-melatonin. Chlorpromazine has no effect on the level of H3-melatonin when the indole is administered to rats by injection into the lateral cerebral ventricle. Chlorpromazine inhibits the in vitro metabolism of H3-melatonin by liver slices, suggesting that the drug alters the tissue levels of the indole by slowing its metabolism. Chronic treatment with phenobarbital causes a decreased H3-melatonin concentration in the brain 30 min after i.v. injection of the indole. © 1968 by The Williams & Wilkins Company