PT  - JOURNAL ARTICLE
AU  - Sheehy, Maureen
AU  - Way, James L.
TI  - EFFECT OF OXYGEN ON CYANIDE INTOXICATION III. MITHRIDATE
DP  - 1968 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 163--168
VI  - 161
IP  - 1
4099  - http://jpet.aspetjournals.org/content/161/1/163.short
4100  - http://jpet.aspetjournals.org/content/161/1/163.full
SO  - J Pharmacol Exp Ther1968 May 01; 161
AB  - Cyanide intoxication in mice can be antagonized by the administration of oxygen, especially when the oxygen is given in combination with the conventional cyanide antidotes, sodium nitrite and sodium thiosuhfate. Potency ratios, derived from the LD50 values, were compared in groups of mice treated with sodium thiosulfate, sodium nitrite and different concentrations of oxygen, either alone or in various combinations after potassium cyanide was injected. These results indicate that the administration of oxygen alone provides only minimal antagonism and it enhances the effect of sodium nitrite to only a minor degree. However, oxygen strikingly potentiates the antidotal effect of sodium thiosulfate either alone or in combination with sodium nitrite. © 1968 by The Williams & Wilkins Company