PT  - JOURNAL ARTICLE
AU  - Felix Bergmann
AU  - Abraham Zerachia
AU  - Moshe Chaimovitz
AU  - Yehuda Gutman
TI  - INFLUENCE OF DRUGS, IMPLANTED INTO THE HYPOTHALAMUS, ON THE WATER CONSUMPTION OF RATS
DP  - 1968 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 222--228
VI  - 159
IP  - 1
4099  - http://jpet.aspetjournals.org/content/159/1/222.short
4100  - http://jpet.aspetjournals.org/content/159/1/222.full
SO  - J Pharmacol Exp Ther1968 Jan 01; 159
AB  - The water intake evoked by hypertonic saline is reduced by intraperitoneal injection of milligram quantities of digitoxin into normal rats: the effect is enhanced by bilateral nephrectomy. When deposited bilaterally in the hypothalamus, microgram quantities of the glycoside are sufficient to suppress both spontaneous drinking and the response to a hypertonic stimulus for a considerable period. In addition, the same or slightly larger amounts of digitoxin produce convulsions lasting a few hours. Ethacrynic acid, when implanted into the hypothalamus in quantities of 5 to 25 µg, exerts a strong antidipsic effect but does not evoke convulsions. Furosemide is active only in amounts of about 100 µg, and the effect lasts for only a few days. Likewise, the adipsia observed after hypothalamic implantation of 100 µg of hydrochlorothiazide is of transient character. The antidipsic activity of drugs which have been deposited in the hypothalamus does not Parallel their diuretic effect upon systemic application. © 1968 by The Williams & Wilkins Company