PT  - JOURNAL ARTICLE
AU  - Edward T. Uyeno
TI  - HALLUCINOGENIC COMPOUNDS AND SWIMMING RESPONSE
DP  - 1968 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 216--221
VI  - 159
IP  - 1
4099  - http://jpet.aspetjournals.org/content/159/1/216.short
4100  - http://jpet.aspetjournals.org/content/159/1/216.full
SO  - J Pharmacol Exp Ther1968 Jan 01; 159
AB  - The effects of several hallucinogenic compounds and their nonhallucinogenic analogs were evaluated in an underwater swim alley. Rats were submerged and forced to swim underwater through plastic tubes 3.47 m long in order to escape at the other end of the tubes. All of the compounds tested significantly increased the starting latency but only d-amphetamine significantly increased swimming time. The peak effect time for d-lysergic acid diethylamide (LSD-25) and three amphetamine derivatives on latency was 20 mm after the i.p. injection; that for 2-brom-lysergic acid diethylamide (BOL-148) was 40 min. Dose-response curves indicated that the increase in latency was a function of dose. The ED50's for LSD-25, BOL-148, 2,4,5-trimethoxy-amphetamine (TMA-2) hydrochloride, 3,4,5-trimethoxyamphetamine (TMA) hydrochloride, d-amphetamine hydrochloride and 4,5,6-trimethoxyamphetamine (TMA-3) hydrochloride were 1.9, 11.0, 15.0, 31.0, 36.5 and 77.0 µmol/kg, respectively. An analysis of relative effectiveness indicated that LSD-25, TMA-2 and TMA (in descending order) were significantly more effective than their respective nonhallucinogenic analogs. © 1968 by The Williams & Wilkins Company