RT Journal Article SR Electronic T1 CARDIOVASCULAR ACTIONS OF IPROVERATRIL JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 504 OP 509 VO 158 IS 3 A1 Gordon Ross A1 Charles R. Jorgensen YR 1967 UL http://jpet.aspetjournals.org/content/158/3/504.abstract AB Electromagnetic flowmeters were used to determine the effects of iproveratril on cardiac function and on blood flow in the femoral, renal and superior mesenteric arteries of cats anesthetized with pentobarbital. Iproveratril produced vasodilatation in the vascular beds of the small intestine and denervated hind limb but not of the kidney. The hypotensive effect of the agent could be wholly accounted for by peripheral vasodilatation in doses below 0.25 mg/kg. Large doses also reduced cardiac output. All effective doses produced bradycardia even after vagotomy and beta-adrenergic blockade produced by i.v. propranolol. Large doses of iproveratril blocked the chronotropic effects of i.v. isoproterenol but did not prevent the isoproterenol-induced increases of stroke volume and maximum aortic flow rate. © 1967 by The Williams & Wilkins Company