TY - JOUR T1 - CARDIOVASCULAR ACTIONS OF IPROVERATRIL JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 504 LP - 509 VL - 158 IS - 3 AU - Gordon Ross AU - Charles R. Jorgensen Y1 - 1967/12/01 UR - http://jpet.aspetjournals.org/content/158/3/504.abstract N2 - Electromagnetic flowmeters were used to determine the effects of iproveratril on cardiac function and on blood flow in the femoral, renal and superior mesenteric arteries of cats anesthetized with pentobarbital. Iproveratril produced vasodilatation in the vascular beds of the small intestine and denervated hind limb but not of the kidney. The hypotensive effect of the agent could be wholly accounted for by peripheral vasodilatation in doses below 0.25 mg/kg. Large doses also reduced cardiac output. All effective doses produced bradycardia even after vagotomy and beta-adrenergic blockade produced by i.v. propranolol. Large doses of iproveratril blocked the chronotropic effects of i.v. isoproterenol but did not prevent the isoproterenol-induced increases of stroke volume and maximum aortic flow rate. © 1967 by The Williams & Wilkins Company ER -