TY - JOUR T1 - ISOSORBIDE: EFFECTS ON RENAL FUNCTION, RENAL CLEARANCE AND TUBULAR HANDLING AND VOLUME OF DISTRIBUTION IN DOGS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 460 LP - 470 VL - 158 IS - 3 AU - James H. Shinaberger AU - Jack W. Coburn AU - Richard C. Reba AU - Kevin G. Barry AU - Lloyd E. Clayton Y1 - 1967/12/01 UR - http://jpet.aspetjournals.org/content/158/3/460.abstract N2 - Isosorbide was noted in previous studies to produce diuresis after p.o. administration to rats. In the present studies with classical clearance methods, isosorbide administered p.o. was found to produce a consistent osmotic diuresis and saluresis after doses of 1.0 and 2.0 g/kg b.wt. in unanesthetized dogs. Glomerular filtration rate and effective renal plasma flow were not altered. The renal clearance of C14-isosorbide was found to be 80% of infulin and creatinine clearance, approximately equal to urea clearance and related to urinary flow rate. Isosorbide administered i.v. produced less solute excretion than an equimolar dose of mannitol. The space of distribution of C14-isosorbide was found to be 54% b.wt. in intact and nephrectomized dogs. Stop-flow studies demonstrated proximal tubular reabsorption of the compound, believed to be passive in nature for several reasons. © 1967 by The Williams & Wilkins Company ER -