RT Journal Article
SR Electronic
T1 EFFECTS OF ETHANOL AND PENTOBARBITAL ON RELEASE OF ACETYLCHOLINE FROM CEREBRAL CORTEX SLICES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 386
OP 393
VO 158
IS 3
A1 H. Kalant
A1 W. Grose
YR 1967
UL http://jpet.aspetjournals.org/content/158/3/386.abstract
AB Ethanol, 0.11 M, reduces reversibly the amount of acetylcholine released by slices of rat or guinea-pig cerebral cortex incubated in medium containing 5 mM K+; in 15 or 27 mM K+ the acetylcholine release is greater but ethanol has no detectable effect. Pentobarbital has a biphasic effect, low concentrations stimulating and high concentrations inhibiting acetylcholine release. Both the stimulatory and inhibitory effects of pentobarbital are increased by raising the K+ concentration of the medium. In 15 mM K+, ethanol has no effect by itself but enhances the stimulatory effect of 0.01 mM pentobarbital. Brain slices from animals made tolerant to ethanol, by daily administration of intoxicating doses, are refractory to the in vitro effect of ethanol on acetylcholine release. © 1967 by The Williams & Wilkins Company