@article {Rauzzino143, author = {Felix J. Rauzzino and Joseph Seifter}, title = {POTENTIATION AND ANTAGONISM OF BIOGENIC AMINES}, volume = {157}, number = {1}, pages = {143--148}, year = {1967}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {The 24- to 48-hr-old chick lacks an effective blood-brain barrier and thereby provides a useful subject for evaluating the direct action of drugs on the central nervous system. Dose-response curves and their slopes were obtained by intravenously administering biogenic amines or γ-aminobutyric acid either alone or in combination. When these curves for lethargy were compared in chicks, the depressant biogenic amines fell into three groups. When two amines of group A (epinephrine and tryptamine) were administered in combination, potentiation occurred, but, when an amine of group A (epinephrine) was administered in combination with an amine of group B (5-hydroxytryptamine, 5-hydroxytryptophan, l-tryptophan or histamine), increased potentiation occurred. The interaction between 5-hydroxytryptamine, and epinephrine was remarkable in that there was an apparent supersensitivity. The interaction between a group A (epinephrine) and a group C compound (γ-aminobutyric acid) resulted in insignificant potentiation. Epinephrine antagonized the excitement induced by 5-hydroxy-N,N-dimethyltryptamine. Other depressant biogenic amines such as 5-hydroxytryptamine, l-tryptophan and 5-hydroxytryptophan did not antagonize 5-hydroxy-N,N-dimethyltryptamine. The characteristic behavioral response of the depressant amines could not be induced in older chickens because of the presence of an effective blood-brain barrier. {\textcopyright} 1967 by The Williams \& Wilkins Company}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/157/1/143}, eprint = {https://jpet.aspetjournals.org/content/157/1/143.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }