RT Journal Article
SR Electronic
T1 THE SYMPATHETIC NERVOUS SYSTEM AS A HOMEOSTATIC MECHANISM. I. ABSOLUTE NEED FOR SYMPATHETIC NERVOUS FUNCTION IN BODY TEMPERATURE MAINTENANCE OF COLD-EXPOSED RATS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 103
OP 110
VO 157
IS 1
A1 R. P. Maickel
A1 N. Matussek
A1 D. N. Stern
A1 B. B. Brodie
YR 1967
UL http://jpet.aspetjournals.org/content/157/1/103.abstract
AB The responses of intact rats to cold-exposure (4°C) include vasoconstriction, piloerection, shivering, adrenocorticotrophin (ACTH) hypersecretion and increased mobilization of free fatty acids and glucose. Adrenal demedullation prevents the increased mobilization of glucose and decreases survival time. Chemical sympathectomy blocks all of the responses except ACTH hypersecretion. Such animals lose body heat rapidly and die in a few hours. Total adrenalectomy has a similar effect. The damaging actions of chemical sympathectomy are reversed by administration of catecholamines while those of total adrenalectomy are reversed by cortisone. Thus, the sympathetic nervous system appears to be essential for existence at low environmental temperature. The effects of adrenalectomy can be attributed to a breakdown of sympathetic response at end-organs due to a lack of steroids. © 1967 by The Williams & Wilkins Company