RT Journal Article
SR Electronic
T1 A COMPARISON OF THE ANTIARRHYTHMIC ACTIONS OF TWO NEW SYNTHETIC COMPOUNDS, IPROVERATRIL AND MJ 1999, WITH QUINIDINE AND PRONETHALOL
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 331
OP 338
VO 156
IS 2
A1 Jack R. Schmid
A1 Calvin Hanna
YR 1967
UL http://jpet.aspetjournals.org/content/156/2/331.abstract
AB The antiarrhythmic actions of MJ 1999 (4-(2-iso-propylamino-1-hydroxyethyl)methanesulfonanilide hydrochloride) and iproveratril were compared with the reference drugs quinidine and pronethalol against four types of experimentally-induced cardiac arrhythmias in dogs. Quinidine was consistently the most effective of the four compounds tested, suppressing 89% of all arrhythmias treated. Iproveratril in very small doses was effective against all four types of experimentally-induced arrhythmias, especially against the ventricular arrhythmias induced by hydrocarbonepinephrine and ouabain. The range of its potency on a micrograms per kilogram basis was from approximately twice that of quinidine and pronethalol against aconitine-induced atrial arrhythmias to about 30 times that of quinidine and pronethalol vs. coronary artery ligation-induced ventricular arrhythmias. The beta-adrenergic receptor blocking compound MJ 1999 was not effective in suppressing ouabain-induced tachycardia, but it was effective in suppressing aconitine- and coronary artery ligation-induced arrhythmias. MJ 1999 was highly effective in blocking hydrocarbon-epinephrine-induced arrhythmias at a dose that was in the range of its beta-adrenergic receptor blocking dose. MJ 1999 had an antiarrhythmic potency approximately twice that of pronethalol against all arrhythmias except ouabain-induced tachycardia. © 1967 by The Williams & Wilkins Company