RT Journal Article
SR Electronic
T1 CARDIOVASCULAR AND MYOCARDIAL METABOLIC EFFECTS OF INFUSIONS OF PHENYLEPHRINE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 325
OP 330
VO 156
IS 2
A1 Philip J. Privitera
A1 Ira Rosenblum
YR 1967
UL http://jpet.aspetjournals.org/content/156/2/325.abstract
AB The cardiovascular and metabolic effects of phenylephrine were investigated in dogs with particular emphasis on correlations with myocardial oxygen (O2) uptake. Phenylephrine could be shown to increase myocardial O2 uptake but only at doses which also caused a significant increase in mean systolic pressure (MSP). The myocardial O2 uptake was always strongly correlated with the product of MSP and heart rate (HR) in these dogs both before and during infusion of the drug. Reflex bradycardia, which accompanied the rise in MSP, probably had the effect of limiting myocardial O2 uptake. This was established, in part, by infusion of drug in vagotomized animals with fixed HR and in animals in which the vagus was stimulated directly. The cardiovascular effects of phenylephrine were also accompanied by hyperglycemia, but the plasma levels of nonesterified fatty acids were not changed. The results of these experiments suggest that phenylephrine causes increased myocardial O2 uptake only in proportion to increased cardiac work and therefore is not an O2-wasting sympathomimetic amine. © 1967 by The Williams & Wilkins Company