RT Journal Article
SR Electronic
T1 THE EFFECT OF XYLOCAINE ON OXYGEN CONSUMPTION IN THE FROG SARTORIUS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 456
OP 462
VO 155
IS 3
A1 I. Novotny
A1 C. P. Bianchi
YR 1967
UL http://jpet.aspetjournals.org/content/155/3/456.abstract
AB In contrast to procaine, Xylocaine does not inhibit the extra oxygen consumption induced by caffeine or potassium depolarization. Xylocaine increases the extra oxygen consumption which can occur without any mechanical changes. If the muscle is made mechanically refractory by high concentrations of potassium, Xylocaine has no effect on respiration. The effect of Xylocaine depends upon extracellular pH, which determines the ratio of charged to uncharged forms; at pH 6.0, when the predominant form of Xylocaine is charged, the stimulatory effect on respiration is abolished. The influence of Xylocaine on the oxygen consumption is thought to be related to the level of free Ca in the cell; the effect does not disappear when Ca is omitted from the Ringer's solution. © 1967 by The Williams & Wilkins Company