RT Journal Article
SR Electronic
T1 STUDIES ON THE ABSORPTION, EXCRETION AND METABOLISM OF DIMETHYLSULFOXIDE (DMSO) IN MAN
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 309
OP 317
VO 155
IS 2
A1 H. B. Hucker
A1 J. K. Miller
A1 A. Hochberg
A1 R. D. Brobyn,
A1 F. H. Riordan
A1 B. Calesnick
YR 1967
UL http://jpet.aspetjournals.org/content/155/2/309.abstract
AB The absorption, excretion and metabolism of dimethylsulfoxide (DMSO) have been studied in man by gas chromatography and radiometric techniques. The drug was readily absorbed when administered dermally, peak serum levels occurring after 4 to 8 hr. Orally administered drug was rapidly absorbed, reaching a peak in serum in 4 hr. Serum levels of DMSO were undetectable after 120 hr. Both unchanged drug and a metabolite, dimethylsulfone (DMSO2), were isolated from urine. DMSO2 appeared in serum after about 48 hr and persisted in serum for as long as 400 hr. Urinary excretion of DMSO after dermal and oral administration amounted to approximately 13% and 30 to 68% of the dose, respectively. Excretion of DMSO2 was about 5 to 10% and 21 to 23%, respectively. Data for subjects given DMSO chronically are also presented, as is evidence that the fraction of DMSO excreted is entirely accounted for by unchanged drug and DMSO2. © 1967 by The Williams & Wilkins Company