PT  - JOURNAL ARTICLE
AU  - Luis E. Folle
AU  - Domingo M. Aviado
TI  - THE CARDIOPULMONARY EFFECTS OF QUINIDINE AND PROCAINAMIDE
DP  - 1966 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 92--102
VI  - 154
IP  - 1
4099  - http://jpet.aspetjournals.org/content/154/1/92.short
4100  - http://jpet.aspetjournals.org/content/154/1/92.full
SO  - J Pharmacol Exp Ther1966 Oct 01; 154
AB  - In the anesthetized dog, the intravenous injection of quinidine consistently induces a fall in systemic blood pressure hut a biphasic rise and fall in pulmonary arterial pressure. The femoral and pulmonary blood vessels are dilated but the heart is initially stimulated and depressed. All these effects are manifestations of local actions of quinidine on the heart and blood vessels, except the cardiac stimulation. Like quinidine, procainamide dilates the pulmonary and femoral blood vessels and depresses the heart. Unlike quinidine, procainamide induces a pure fall in pulmonary arterial pressure. © 1966 by The Williams & Wilkins Company