RT Journal Article
SR Electronic
T1 THE EFFECTS OF RESERPINE ON BEHAVIOR AND ON BRAIN CONCENTRATIONS OF SEROTONIN AND NOREPINEPHRINEIN CONTROL RATS AND RATS WITH HYPOTHALAMIC LESIONS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 401
OP 411
VO 153
IS 3
A1 FRANK GRABARITS
A1 JOHN A. HARVEY
YR 1966
UL http://jpet.aspetjournals.org/content/153/3/401.abstract
AB Rats with lesions in the medial forebrainbundle demonstrate significant decreases in brain concentrations of serotonin and norepinephrine without showing signs of sedation. Nevertheless, these lesioned animals do demonstrate an increased sensitivity to the sedative action of reserpine as measured by depression of lever pressing for water reward. The present study examined this increased sensitivity toreserpine. For any given dosage of reserpine, rats with medial forebrain bundle lesions demonstrated lower final concentrations of brain amines and an associated greater sedation ascompared with control rats given the same dosage of drug. The greater behavioral sensitivity to reserpine produced by these lesions could be accounted for by the additive effects of drug and lesion on brain amine concentrations. Similar results were obtained by premedication of nonlesioned animals with reserpine. Degree of sedation and brain concentrations of amines were significantly and highly correlated in individual animals at 2,20 and 50 hr after reserpine injection. However, the curve relating sedation to amine concentration was shifted to the rightby 50 hr. © 1966 by The Williams & Wilkins Co.