PT  - JOURNAL ARTICLE
AU  - FRANK GRABARITS
AU  - JOHN A. HARVEY
TI  - THE EFFECTS OF RESERPINE ON BEHAVIOR AND ON BRAIN CONCENTRATIONS OF SEROTONIN AND NOREPINEPHRINEIN CONTROL RATS AND RATS WITH HYPOTHALAMIC LESIONS
DP  - 1966 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 401--411
VI  - 153
IP  - 3
4099  - http://jpet.aspetjournals.org/content/153/3/401.short
4100  - http://jpet.aspetjournals.org/content/153/3/401.full
SO  - J Pharmacol Exp Ther1966 Sep 01; 153
AB  - Rats with lesions in the medial forebrainbundle demonstrate significant decreases in brain concentrations of serotonin and norepinephrine without showing signs of sedation. Nevertheless, these lesioned animals do demonstrate an increased sensitivity to the sedative action of reserpine as measured by depression of lever pressing for water reward. The present study examined this increased sensitivity toreserpine. For any given dosage of reserpine, rats with medial forebrain bundle lesions demonstrated lower final concentrations of brain amines and an associated greater sedation ascompared with control rats given the same dosage of drug. The greater behavioral sensitivity to reserpine produced by these lesions could be accounted for by the additive effects of drug and lesion on brain amine concentrations. Similar results were obtained by premedication of nonlesioned animals with reserpine. Degree of sedation and brain concentrations of amines were significantly and highly correlated in individual animals at 2,20 and 50 hr after reserpine injection. However, the curve relating sedation to amine concentration was shifted to the rightby 50 hr. © 1966 by The Williams & Wilkins Co.