TY - JOUR T1 - THE PHYSIOLOGIC DISPOSITION OF H<sup>3</sup>-HISTAMINE IN THE RAT BRAIN JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 8 LP - 14 VL - 153 IS - 1 AU - Solomon H. Synder AU - Jacques Glowinski AU - Julius Axelrod Y1 - 1966/07/01 UR - http://jpet.aspetjournals.org/content/153/1/8.abstract N2 - The physiologic disposition of H3-histamine in rat brain has been studied after its intraventricular administration. H3-histamine is taken up and retained in the brain. H3-histamine disappears from the brain in a multiphasic fashion with a half-life of 1.6 hr during the first 6 hr and a half-life of 11 hr from 6 to 24 hr. The major metabolic product of H3-histamine in brain is H3 imidazoleacetic acid; a minor product is H3-methylhistamine. Subcellular distribution studies using a continuous sucrose gradient showed that the H3-histamine is highly localized in the pinched-off nerve ending and microsomal fractions. Monoamine oxidase inhibition elevates H3-histamine levels in rat brain. Reserpine and aminoguanidine have no effect. The Williams &amp; Wilkins Comapny ER -