TY - JOUR T1 - THE EFFECTS OF NOREPINEPHRINE ISOMERS ON VARIOUS SUPERSENSITIVITIES OF THE CAT NICTITATING MEMBRANE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 81 LP - 89 VL - 153 IS - 1 AU - R. J. Seidehamel AU - P. N. Patil AU - A. Tye AU - J. B. LaPidus Y1 - 1966/07/01 UR - http://jpet.aspetjournals.org/content/153/1/81.abstract N2 - Superesensitivity of the cat nictitating membrane produced by chronicpretreatment with reserpine, decentralization or denervation was investigated to determine possible stereospecificity between D(-)- and L(+)-norepinephrine. Nictitating membrane contractions of spinal cats in response to isomers (intravenously injected) were magnified and recorded on a drum with an isotonic lever system. The degree of sensitization was determined by measuring horizontal shifts of dose-response curves for sensitized preparations to the left of their controls at the ED20 mm level. Supersensitivity caused by chronic pretreatment with reserpine or denervation is stereospecific for D(-)-as against L(+)- norepinephrine. However, after acute pretreatment of the preparations with reserpine, decentralization but not denervation supersensitivity is stereospccific in the same manner. The Williams & Wilkins Comapny ER -