RT Journal Article
SR Electronic
T1 A RELATIVELY NONSPECIFIC SUPERSENSITIVITY IN AORTIC STRIPS RESULTING FROM PRETREATMENT WITH RESERPINE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 70
OP 80
VO 153
IS 1
A1 Patricia M. Hudgins
A1 William W. Fleming
YR 1966
UL http://jpet.aspetjournals.org/content/153/1/70.abstract
AB The effects of several schedules of pretreatment with reserpine on the sensitivity of the isolated aortic strip of the rabbit have been studied. The following treatments were employed: 1 mg/kg/day for 1 day, 3 mg/kg/day for 1 day, 0.3 mg/kg/day for 3 days, 1 mg/kg/day for 3 days, 0.3 mg/kg/day for 7 days and 0.3 mg/kg/day for 14 days. All treatments caused a shift to the right of the dose-response curve of tyramine, indicating subsensitivity. There was no reduction in maximum. The responses to tyramine were only slightly antagonized by phentolamine. All treatments with reserpine caused a shift to the left of the dose-response curve of norepinephrine (supersensitivity). The optimal schedule of treatment with reserpine was determined to be 0.3 mg/kg/day for 3 days. The sensitivity was also increased to acetylcholine and potassium, but not to 5-hydroxytryptamine, histamine or angiotensin. A dose of phentolamine which produced marked antagonism against norepinephrine caused very little antagonism of acetylcholine and none of potassium. Pretreatment of cats with reserpine, 0.1 mg/kg/day for 3 days, produced supersensitivity to norepinephrine in aortic strips from that species also. The nonspecific nature of the supersensitivity is discussed as evidence that the supersensitivity is due to a physiologic change beyond the receptors. The Williams & Wilkins Comapny