PT - JOURNAL ARTICLE AU - Eino Nelson AU - Manabu Hanano AU - Gerhard Levy TI - COMPARATIVE PHARMACOKINETICS OF SALICYLATE ELIMINATION IN MAN AND RATS DP - 1966 Jul 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 159--166 VI - 153 IP - 1 4099 - http://jpet.aspetjournals.org/content/153/1/159.short 4100 - http://jpet.aspetjournals.org/content/153/1/159.full SO - J Pharmacol Exp Ther1966 Jul 01; 153 AB - The rat, like man, has only limited capacity for the synthesis of salicylurate from salicylate and glycine. The administration of glycine has no effect on the metabolism of salicylate in man and rats or on the toxicity of salicylate in rats. Pharmacokinetic constants for salicylurate formation are in good agreement with apparent in vivo Km and Vmax values obtained from appropriate Lineweaver-Burk plots. In vivo Km values are the same in man and rats, but Vmax is about 4 times higher in man, on a body weight basis, than in rats. The Williams & Wilkins Comapny