RT Journal Article SR Electronic T1 THE RENAL EXCRETION OF ETHYLENEDIAMINETETRAACETATE IN THE DOG JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 142 OP 147 VO 153 IS 1 A1 Marvin Forland A1 Theodore N. Pullman A1 A. R. Lavender A1 Impi Aho YR 1966 UL http://jpet.aspetjournals.org/content/153/1/142.abstract AB The renal excretion of calcium-ethylenediaminetetraacetic acid (EDTA) has been studied in 38 dogs by means of clearance techniques and competitive and selective tubular transport inhibition. In 60 periods, the renal clearance of EDTA closely approximated the inulin clearance with an EDTA/inulin clearance ratio of 1.02 ± 0.07. Probenecid, N'- methylnicotinamide and cyanine 863 had no specific inhibitory effect on the renal clearance of EDTA. Neither urinary acidification, alkalinization nor increasing urine flow attributa- ble to a solute diuresis appreciably influenced its excretion. EDTA appears to be excreted by glomerular filtration independent of the primary secretory pathways of acidic or basic compounds and without significant reabsorption. Determination of EDTA clearance represents an additional means of measuring glomerular filtration rate in the dog. The Williams & Wilkins Comapny