RT Journal Article
SR Electronic
T1 RELATIVE EFFECTS OF 17α-ALKYLATED ANABOLIC STEROIDS ON SULFOBROMOPHTHALEIN (BSP) RETENTION IN RABBITS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 143
OP 150
VO 151
IS 1
A1 Lennon, Harry D.
YR 1966
UL http://jpet.aspetjournals.org/content/151/1/143.abstract
AB Measurement of sulfobromophthalein (BSP) retention in rabbits was shown to be a simple laboratory test for estimating the effects of anabolic steroids on hepatic excretory function. Non-17α-alkylated androgen-anabolic steroids failed to alter serum BSP levels, whereas 17α-alkylated anabolic steroids caused increased BSP retention when these steroids were given orally to rabbits at 10 and 20 mg/kg of body weight daily for 4 days. The magnitude of effects on BSP retention in the rabbit varied among the various l7α-alkylated steroids and did not appear to be related to myotrophic or androgenic activities, although some correlation was apparent with nitrogen-retaining activity in rats. Several published clinical reports indicated that the relative effects of 17α-alkylated anabolic steroids on BSP retention in human patients were similar to those effects observed in rabbits. The Williams & Wilkins Comapny