RT Journal Article
SR Electronic
T1 SELECTIVITY OF ESTROGEN DISTRIBUTION IN TISSUES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 469
OP 475
VO 150
IS 3
A1 Eisenfeld, Arnold J.
A1 Axelrod, Julius
YR 1965
UL http://jpet.aspetjournals.org/content/150/3/469.abstract
AB Circulating estradiol is selectively accumulated by the anterior pituitary, uterus, vagina, hypothalamus, septum and preoptic region. Pretreatment with the progestin norethynodrel reduced the H3-estradiol concentrations in the anterior pituitary, uterus, vagina, heart, adrenal, hypothalamus, preoptic region and septum. Treatment with norethynodrel after H3-estradiol administration reduced the radioactive concentration only in the uterus and vagina. Norethynodrel appeared to function as a competitive inhibitor of estradiol for binding. Evidence has been presented for an estradiol saturable binding mechanism in the anterior pituitary, uterus, vagina, and hypothalamus. The Williams & Wilkins Comapny