PT - JOURNAL ARTICLE AU - Eisenfeld, Arnold J. AU - Axelrod, Julius TI - SELECTIVITY OF ESTROGEN DISTRIBUTION IN TISSUES DP - 1965 Dec 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 469--475 VI - 150 IP - 3 4099 - http://jpet.aspetjournals.org/content/150/3/469.short 4100 - http://jpet.aspetjournals.org/content/150/3/469.full SO - J Pharmacol Exp Ther1965 Dec 01; 150 AB - Circulating estradiol is selectively accumulated by the anterior pituitary, uterus, vagina, hypothalamus, septum and preoptic region. Pretreatment with the progestin norethynodrel reduced the H3-estradiol concentrations in the anterior pituitary, uterus, vagina, heart, adrenal, hypothalamus, preoptic region and septum. Treatment with norethynodrel after H3-estradiol administration reduced the radioactive concentration only in the uterus and vagina. Norethynodrel appeared to function as a competitive inhibitor of estradiol for binding. Evidence has been presented for an estradiol saturable binding mechanism in the anterior pituitary, uterus, vagina, and hypothalamus. The Williams & Wilkins Comapny