PT  - JOURNAL ARTICLE
AU  - Eisenfeld, Arnold J.
AU  - Axelrod, Julius
TI  - SELECTIVITY OF ESTROGEN DISTRIBUTION IN TISSUES
DP  - 1965 Dec 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 469--475
VI  - 150
IP  - 3
4099  - http://jpet.aspetjournals.org/content/150/3/469.short
4100  - http://jpet.aspetjournals.org/content/150/3/469.full
SO  - J Pharmacol Exp Ther1965 Dec 01; 150
AB  - Circulating estradiol is selectively accumulated by the anterior pituitary, uterus, vagina, hypothalamus, septum and preoptic region. Pretreatment with the progestin norethynodrel reduced the H3-estradiol concentrations in the anterior pituitary, uterus, vagina, heart, adrenal, hypothalamus, preoptic region and septum. Treatment with norethynodrel after H3-estradiol administration reduced the radioactive concentration only in the uterus and vagina. Norethynodrel appeared to function as a competitive inhibitor of estradiol for binding. Evidence has been presented for an estradiol saturable binding mechanism in the anterior pituitary, uterus, vagina, and hypothalamus. The Williams & Wilkins Comapny